Clinical trials are experiments designed to evaluate new interventions to prevent or treat disease in humans. The interventions evaluated can be drugs, devices (e.g., hearing aid), surgeries, behavioral interventions (e.g., smoking cessation program), community health programs (e.g. cancer screening programs) or health delivery systems (e.g., special care units for hospital admissions). We consider clinical trials experiments because the investigators rather than the patients or their doctors select the treatment the patients receive. Results from randomized clinical trials are usually considered the highest level of evidence for determining whether a treatment is effective because trials incorporates features to ensure that evaluation of the benefits and risks of treatments are objective and unbiased. The FDA requires that drugs or biologics (e.g., vaccines) are shown to be effective in clinical trials before they can be sold in the US.
von
Design and Interpretation of Clinical Trials
Über diesen Kurs
Karriereergebnisse der Lernenden
39%
36%
14%
Zertifikat zur Vorlage
100 % online
Flexible Fristen
Ca. 10 Stunden zum Abschließen
Englisch
Kompetenzen, die Sie erwerben
Karriereergebnisse der Lernenden
39%
36%
14%
Zertifikat zur Vorlage
100 % online
Flexible Fristen
Ca. 10 Stunden zum Abschließen
Englisch
von
Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
Lehrplan - Was Sie in diesem Kurs lernen werden
Types of Trial Designs
This week, we explore different types of trial designs, including parallel, crossover, group allocation, factorial, large simple, equivalency, non-inferiority, and adaptive designs.
Randomization and Masking
This week we discuss two key design features of randomized clinical trials used to protect against bias, randomization and masking.
Outcomes and Analysis
This week focuses on a key design issue - selecting the primary outcome. We will also cover the gold standard for analysis of clinical trials, which is including all the participants in the analysis regardless of their actual treatment.
Ethics
This week focuses on a key issue in the field of clinical trials, the ethics of experimentation in humans.
Bewertungen
Top-Bewertungen von DESIGN AND INTERPRETATION OF CLINICAL TRIALS
High quality course ! covering important areas and detailed lectures, more and better than a mere introduction. Congrats ! My only regret : I'd have liked to hear more about NI and equivalence trials
This course would be most useful to the participant if pursued within a short time-frame, of maximum of 6 weeks. Both lecturers were clear and good communicators. I would take more of their classes.
Excellent beginner course on design and interpretation of clinical trials, complements a lot of what I reviewed on my classes and I would like to take a more advanced course on the topic. Thank you.
This course is well-designed, well-paced and well-structured. The study examples described in this course really help you understand the importance of design and interpretation of clinical trials.
The instructors have broken down the concepts in a very effective manner and have designed very thoughtful discussion prompts. The course really helped me understand the basics of clinical trials.
One of the best online courses I have taken so far at Coursera. Very helpful if you are new to the field and helps you to understand and interpret clinical data. I highly recommend this course.
The powerpoints and audio lectures are very clear and concise, much appreciated. I would also appreciate more exercises or reading materials, to help solidify our understanding of the topics.
Great course for not only a better understanding of the clinically directed people but also for sales professionals to help understand and discuss clinical findings for their products.
Succinct course which includes a good overview of clinical trial design as well as additional readings for deeper understanding of FDA requirements and guidelines for clinical trials.
I work as a protocol activation coordinator for a large clinical trials office. I am new to this role and this course was very valuable in helping me get started with this career
Very informative and well structured. Pleasure to learn!\n\nI will definitely expand on my knowledge with further studies on these topics inspired by the excellent presenters.
Extremely useful for scholars and post-grad students, or really, anyone who is interested to work in the field of Clinical Research. Thank you for a brilliant compilation!
This course gives a excellent overview of design and interpretation of clinical trials. I recommend it for all graduate students and people involved in clinical research.
It's very informative , with lots of essential info. about clinical trials , If you interested in knowing the fundamentals of clinical trials , so this course is worthy !
I really enjoyed the course and believe the information was really beneficial. They gave great examples of studies that included the techniques that were being reviewed.
Very comprehensive and understandable. Thanks for uploading such an informative course. Now I will read the method section of the article that I use to skip very often.
The course clearly explains the concepts of clinical trials with great detail. The course was taught in a structured manner and helped me gain knowledge in this field.
Great course for people in clinical research field. This intense information on randomization and clinical trail design is very helpful to me to advance my skill sets
Pitched at the right level as an introductory course. Having some exposure to clinical trials helps complete in a timely manner, but there's still a lot to learn
Great introduction to RCTs. As a data scientist, I found the discussions on the different RCT designs, as well as the methods for randomization, very valuable.
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