Synbio is a diverse field with diverse applications, and the different contexts (e.g., gain-of-function research, biofuels) raise different ethical and governance challenges. The objective of this course is to increase learners’ awareness and understanding of ethical and policy/governance issues that arise in the design, conduct and application of synthetic biology. The course will begin with a short history of recombinant DNA technology and how governance of that science developed and evolved, and progress through a series of areas of application of synbio.
Content will be presented in many forms, including not only reading and lectures, but also recorded and live interviews and discussions with scientists, ethicists and policy makers. Learners will have the opportunity to think, write and talk about the issues and challenges in their own work and in real-life case examples. A final project will engage students in the development of governance models for synbio.
Engineering Life: Synbio, Bioethics & Public Policy
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Johns Hopkins University
Lehrplan - Was Sie in diesem Kurs lernen werden
Woche
118 Minuten zum Abschließen
Welcome to Engineering Life: SynBio, Bioethics & Public Policy
1 Video (Gesamt 3 min), 1 Lektüre
1 Video
1 Lektüre
Syllabus: Engineering Life10m
2 Stunden zum Abschließen
Recombinant DNA Technology: Science and History
We start the course by learning a bit about the history and context of the development of recombinant DNA (rDNA) technology in the 1970s, the ethics and policy issues raised by that science, and how those issues remain with us today in synthetic biology. The work of the week includes lecture videos, readings, and an interview with LeRoy Walters, who was involved in the discussions and debates about rDNA in its early years. The week will conclude with a quiz.
8 Videos (Gesamt 105 min), 1 Lektüre, 1 Quiz
8 Videos
A Brief History of rDNA15m
A Brief History of Asilomar & the RAC19m
Interview: Dr. LeRoy Walters (Part 1)19m
Interview: Dr. LeRoy Walters (Part 2)21m
Interview: Dr. LeRoy Walters (Part 3)12m
Relevant Contemporary Policy Context5m
The Emergence of SynBio9m
1 Lektüre
Week 1 Readings10m
1 praktische Übung
Week 1 Quiz30m
Woche
23 Stunden zum Abschließen
GOF Research
In Week 2 we will learn about and discuss gain of function (GOF) research and the dual-use concerns raised by synthetic biology. The work of the week includes lecture videos, a number of outside videos, and readings. The assessment this week will be your first peer-assessed project, and will focus on identifying ethical duties related to GOF research policy.
6 Videos (Gesamt 49 min), 2 Lektüren, 1 Quiz
6 Videos
Gain of Function Research5m
Dual Use Research9m
GOF Research Case Study: H5N112m
Ethical Issues Raised by GOF Research11m
Governance and GOF Research9m
2 Lektüren
Week 2 Readings10m
Additional Video Content10m
Woche
32 Stunden zum Abschließen
Biofuels
This week, we’ll learn about biofuels, the complex task of balancing the many ethical issues they raise, and the role of synthetic biology in biofuels development. The work of the week includes lecture videos, one outside video, readings, and an interview with Deborah Scott about biofuels governance. The week will conclude with a quiz.
7 Videos (Gesamt 69 min), 2 Lektüren, 1 Quiz
7 Videos
Biofuels9m
Applications5m
Case Study4m
Ethical Issues Raised by SynBio-based Biofuels8m
Interview: Deborah Scott, PhD, JD (Part 1)24m
Interview: Deborah Scott, PhD, JD (Part 2)14m
2 Lektüren
Week 3 Readings10m
Additional Video Content10m
1 praktische Übung
Week 3 Quiz30m
Woche
43 Stunden zum Abschließen
Human Health
This week we will learn a bit about applications of synthetic biology to human health, and the ethics of human subjects research. The work of the week includes lecture videos, one outside video, and readings. The assessment this week will be your second peer-assessed project, and will build on your first project, from Week 2. This project will focus on identifying stakeholders in a policy decision, their interests in the decision, and the related ethical duties of the decision-maker.
7 Videos (Gesamt 50 min), 2 Lektüren, 1 Quiz
7 Videos
Synbio in Human Health5m
Human Genetic Modification6m
Case Study: Artemisinin6m
Case Study: GM Mosquitos8m
Ethical Issues Raised by SynBio-based Medical Applications13m
Governance of SynBio-based Medical Applications7m
2 Lektüren
Week 4 Readings10m
Additional Video Content10m
33%
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Top-Bewertungen
fun and interesting course. very well taught by somebody obviously knowledgeable. Thanks so much.
Highly thought-provoking. One of the most interesting classes I have taken on Coursera.
Dozent
Debra JH Mathews, PhD, MA
Assistant Director for Science ProgramsBerman Institute of Bioethics
Über Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
Häufig gestellte Fragen
Wann erhalte ich Zugang zu den Vorträgen und Aufgaben?
Sobald Sie sich für ein Zertifikat angemeldet haben, haben Sie Zugriff auf alle Videos, Quizspiele und Programmieraufgaben (falls zutreffend). Aufgaben, die von anderen Kursteilnehmern bewertet werden, können erst dann eingereicht und überprüft werden, wenn Ihr Unterricht begonnen hat. Wenn Sie sich den Kurs anschauen möchten, ohne ihn zu kaufen, können Sie womöglich auf bestimmte Aufgaben nicht zugreifen.
Was bekomme ich, wenn ich das Zertifikat erwerbe?
Wenn Sie ein Zertifikat erwerben, erhalten Sie Zugriff auf alle Kursmaterialien, einschließlich bewerteter Aufgaben. Nach Abschluss des Kurses wird Ihr elektronisches Zertifikat zu Ihrer Seite „Errungenschaften“ hinzugefügt – von dort können Sie Ihr Zertifikat ausdrucken oder es zu Ihrem LinkedIn Profil hinzufügen. Wenn Sie nur lesen und den Inhalt des Kurses anzeigen möchten, können Sie kostenlos als Gast an dem Kurs teilnehmen.
Wie erfolgen Rückerstattungen?
Ist finanzielle Unterstützung möglich?
What is the most important thing I'll learn if I take this class?
The primary goal of this class is to help scientists think a bit more like policy makers and the public, seeing not only the incredible promise of the science they do, but also the potential risks and pitfalls, so these can be avoided or designed against at the beginning of a project, rather than at the end, when the challenges and costs are higher. Working with scholars, policy makers, and fellow learners, students will gain a greater understanding and appreciation of the ethics and governance of synthetic biology.
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