In this course, youâ€™ll learn more advanced operational skills that you and your team need to run a successful clinical trial. Youâ€™ll learn about the computation of sample size and how to develop a sample size calculation thatâ€™s suitable for your trial design and outcome measures. Youâ€™ll also learn to use statistical methods to monitor your trial for safety, integrity, and efficacy. Next, youâ€™ll learn how to report the results from your clinical trials through both journal articles and data monitoring reports. Finally, weâ€™ll discuss the role of the analyst throughout the trial process, plus a few additional topics such as simulations and adaptive designs.