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Introduction to Systems Biology, Icahn School of Medicine at Mount Sinai

297 Bewertungen
55 Bewertungen

Über diesen Kurs

This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses....


von SV

Feb 07, 2016

Very useful course in order to learn the basics in systems biology. You only need some training in biology to understand the concepts but the course is easy to follow and very complete.

von JR

May 03, 2018

It's a challenging subject. Don't expect to walk away from the course with a complete grasp of systems biology. However, this course is a fantastic place to start.

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53 Bewertungen

von Saad Rashid Usmani

Apr 28, 2019


von Radu Angelescu

Apr 21, 2019

Tests do not reflect course information. Even if the title is "introduction" it asumes the user is familiar with a lot of topics. It is probably good for people that just need a reminder of something that they studied previousely.

They teach basic theory and then require the student to know much more on exams. Maybe this course should be done last in the specialization. (I'm hoping the others are better)

von Saketh Chalasani

Apr 10, 2019


von Raul Garcia

Mar 18, 2019

An exceptional course for anyone interested in the area of bioinformatics, cell biology, biotechnology, etc. I think it is very valuable to have some background in molecular biology but if you are interested, do not doubt to take it.

von Aakash Sudhakar

Feb 23, 2019

Dr. Iyengar was a cool guy.

von Himanshu

Feb 21, 2019

Although I am thankful to the Icahn School of Medicine at Mount Sinai, Ravi Iyengar & colleagues and especially Coursera for providing the such courses online,

I have to say after taking this course that I did not find this helpful and would not really recommend it to anyone. The course is sort of a bird's eye view of the field of systems biology such that a beginner would not understand much of anything and an experienced researcher would also not really benefit from it either. In my view the course is sort of a "Review of certain handpicked literature" and it does not Explain well the basic concepts of system biology.

von Oscar Wilkins

Dec 02, 2018

A good introduction to this topic for sure. As others have said, this is perhaps more like an "advanced" course than intermediate (I already have a masters in biochemistry and a lot of programming experience) but for me it's perfect. He does talk slowly though so I've been increasing the play speed to 1.5x

von Adrián Posado Fernández

Nov 18, 2018

This sort of course will be kind of useful for sort of improving your knowledge on a sort of concepts related to some kind of areas related to sort of Systems Biology. :) That´s just an innocent joke you will catch if you complete the course. Well, the course could be very useful if you are not especially familiar with Systems Biology, as it was my case. You won't learn how to develop a model from "zero" nor how to use Matlab, but it is a comprehensive compendium of theoretical concepts supported by several well-chosen published examples. It is not easy, but it is not extremely difficult (I completed the entire course in 5 days). Thanks to Dr Ravi Iyengar for the talks and his team for the course. However, the speech should have been more dynamic and fluent sometimes, and with less "sort of" repetitions.

von Zahra Azam

Oct 25, 2018

I did the first course in this specialization series and it was way too difficult for me as only a highschool graduate. The course is basically for advanced students who do scientific research in this system biology field. The course is enormous with a lot of things to cover in just 15 minutes lecture video. So you have to do a lot of personal reading and research for terms used by the lecturer. My advice to fellow learners choosing this course means you need to put a lot of passion, dedication and self motivation for completion of the course. So Good luck.

Though I Feel truly accomplished by finishing this difficult course and challenging myself to new boundaries where i thought I would never make it to. So Thank you Sir. Ravi for that.😁

von Daniel Phillips

Sep 05, 2018

This course is difficult. Often very difficult. Sometimes extremely difficult. However, the assessments are reasonably accessible for someone who is not highly experienced in the relevant fields (i.e molecular biology, biochemistry or mathematical modelling). I enjoyed the course tremendously. The content of the course was stellar, and delivered to me exactly what I was hoping for from this course. When I first began the course I was quite surprised at the level of detail (this is my first time using Coursera, and I had thought the course would be a lot more "fluffy" or "wishy-washy" than it was). The level of detail was paired (almost always) with a description by Ravi Iyengar which was simple and captured the main "take-home" points. This I imagine is only possible thanks to the eminence and experience of Dr Iyengar and the hard-work by the rest of the team behind the scenes. Many aspects can be a little daunting (I did not understand anything with great deepness, I often did not understand things very much, but I rarely did not understand things at all - thanks to the emphasis on take-home points). I think an essential course for anyone who wants a taste of all things systems and networks.